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KMID : 0356420060240030115
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Journal of Korean Andrology
2006 Volume.24 No. 3 p.115 ~ p.125
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The Efficacy of Transdermal Testosterone(Testogel?) in Late Onset Hypogonadism Patients: Changes in Serum Testosterone Level and Symptom Scores Based on Aging Males’ Symptoms Scale
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Bae Jae-Hyun
Kim Jong-Wook
Kim No-Soo
Kim Myung-Joon
Moon Du-Geon
Kim Je-Jong
Park Min-Gu
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Abstract
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Purpose: This study was done to assess the effects of Transdermal testosterone gel(Testogel?) in late onset hypogonadism (LOH) patients and thecorrelation of AMS(aging males’ symptoms) scale with serum testosterone concentration.
Materials and Methods: We reviewed 73 medical records of LOH patients with low serum testosterone level (＜3.5 ng/ml) who had been prescribed 1% Testogel? 5 g for over 3 months. The changes in serum testosterone level and AMS scores after application of Testogel? were statistically analyzed.
Results: Mean age and duration of therapy were 56.0±11.1 years and 195.4±102.9 days, respectively. Compared to before treatment, Testogel? significantly increased the level of serum total testosterone, free testosterone, and bioavailable testosterone at 3, 6, and 9months after treatment, and there were no significant differences in each of these parameters at the 3 time points. Testogel? also significantly improved AMS scores related to sexual dysfunction, somatic function, and psychological function at 3, 6, and 9 months. Among various parameters, serum total testosterone level was highly correlated with the AMS score (r=0.422, p＜0.01). The more severe the complaints were before treatment, the greater the relative improvement. There were no severe systemic adverse reactions in any patients.
Conclusions: Testogel? effectively elevated serum testosterone level and improved AMS scores. The improvement of AMS score was correlated with serumtotal testosterone concentration. Treatment was more effective in patients with more severe symptoms. Large prospective studies are needed to identify the long-term effects of Testogel? in LOH patients.
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KEYWORD
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Late onset hypogonadism, Testogel?, Testosterone, AMS score
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